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Volume 16, issue 22
Atmos. Chem. Phys., 16, 14079-14090, 2016
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
Atmos. Chem. Phys., 16, 14079-14090, 2016
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.

Research article 15 Nov 2016

Research article | 15 Nov 2016

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

Maiko Arashiro et al.
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Cited articles  
Barnes, P. J. and Adcock, I. M.: NF-kB: a pivotal role in asthma and a new target for therapy, Am. J. Physiol, 265, 577–506, 1997.
Bowler, R. P. and Crapo, J. D.: Oxidative stress in allergic respiratory diseases, J. Allergy Clin. Immun., 110, 349–356, https://doi.org/10.1067/mai.2002.126780, 2002.
Budisulistiorini, S. H., Canagaratna, M. R., Croteau, P. L., Marth, W. J., Baumann, K., Edgerton, E. S., Shaw, S. L., Knipping, E. M., Worsnop, D. R., Jayne, J. T., Gold, A., and Surratt, J. D.: Real-Time Continuous Characterization of Secondary Organic Aerosol Derived from Isoprene Epoxydiols in Downtown Atlanta, Georgia, Using the Aerodyne Aerosol Chemical Speciation Monitor, Environ. Sci. Technol., 47, 5686–5694, https://doi.org/10.1021/es400023n, 2013.
Budisulistiorini, S. H., Li, X., Bairai, S. T., Renfro, J., Liu, Y., Liu, Y. J., McKinney, K. A., Martin, S. T., McNeill, V. F., Pye, H. O. T., Nenes, A., Neff, M. E., Stone, E. A., Mueller, S., Knote, C., Shaw, S. L., Zhang, Z., Gold, A., and Surratt, J. D.: Examining the effects of anthropogenic emissions on isoprene-derived secondary organic aerosol formation during the 2013 Southern Oxidant and Aerosol Study (SOAS) at the Look Rock, Tennessee ground site, Atmos. Chem. Phys., 15, 8871–8888, 10.5194/acp-15-8871-2015, 2015.
Budisulistiorini, S. H., Baumann, K., Edgerton, E. S., Bairai, S. T., Mueller, S., Shaw, S. L., Knipping, E. M., Gold, A., and Surratt, J. D.: Seasonal characterization of submicron aerosol chemical composition and organic aerosol sources in the southeastern United States: Atlanta, Georgia,and Look Rock, Tennessee, Atmos. Chem. Phys., 16, 5171–5189, https://doi.org/10.5194/acp-16-5171-2016, 2016.
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Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial SOA. Potential adverse health effects resulting from exposure to this aerosol type are largely unknown. Measurements of gene expression of known inflammatory biomarkers interleukin 8 (IL-8) and cyclooxygenase 2 (COX-2) in exposed human lung cells at the air–liquid interface showed that a dose of 0.067 μg cm−2 of isoprene SOA leads to statistically significant increases in IL-8 and COX-2 mRNA levels.
Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial...
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