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Atmospheric Chemistry and Physics An interactive open-access journal of the European Geosciences Union
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Volume 16, issue 22
Atmos. Chem. Phys., 16, 14079–14090, 2016
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
Atmos. Chem. Phys., 16, 14079–14090, 2016
https://doi.org/10.5194/acp-16-14079-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.

Research article 15 Nov 2016

Research article | 15 Nov 2016

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

Maiko Arashiro et al.
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Status: closed
Status: closed
AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment
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Peer review completion
AR: Author's response | RR: Referee report | ED: Editor decision
AR by Jason Surratt on behalf of the Authors (24 Aug 2016)  Author's response    Manuscript
ED: Reconsider after major revisions (25 Aug 2016) by Yinon Rudich
AR by Jason Surratt on behalf of the Authors (12 Sep 2016)  Author's response    Manuscript
ED: Referee Nomination & Report Request started (12 Sep 2016) by Yinon Rudich
RR by Anonymous Referee #3 (19 Sep 2016)
RR by Anonymous Referee #1 (22 Sep 2016)
RR by Anonymous Referee #2 (24 Sep 2016)
ED: Reconsider after minor revisions (Editor review) (24 Sep 2016) by Yinon Rudich
AR by Anna Mirena Feist-Polner on behalf of the Authors (10 Oct 2016)  Author's response
ED: Publish as is (18 Oct 2016) by Yinon Rudich
Publications Copernicus
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Short summary
Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial SOA. Potential adverse health effects resulting from exposure to this aerosol type are largely unknown. Measurements of gene expression of known inflammatory biomarkers interleukin 8 (IL-8) and cyclooxygenase 2 (COX-2) in exposed human lung cells at the air–liquid interface showed that a dose of 0.067 μg cm−2 of isoprene SOA leads to statistically significant increases in IL-8 and COX-2 mRNA levels.
Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol yields substantial...
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