Abstract. A new version of the High-Resolution Infrared Radiation Sounder (HIRS) upper tropospheric water vapor channel (channel 12) brightness temperature dataset is developed using intersatellite calibrated data. In this dataset, only those pixels affected by upper tropospheric clouds are discarded. Compared to the previous version that was based on column-clear-sky data, the new version has much better daily spatial coverage. The HIRS observation patterns are compared to microwave sounder measurements. The differences between the two types of sounders vary with respect to brightness temperature with larger differences for higher (dry) values. Correlations between the HIRS upper tropospheric water vapor channel brightness temperatures and several major climate indices show strong signals during cold seasons. The selected climate indices track climate variation signals covering regions from the tropics to the poles. Qualitatively, moist signals are correlated with troughs and ascending branches of the circulation, while dry signals occur with ridges and descent. These correlations show the potential of using the upper tropospheric water vapor channel brightness temperature dataset together with a suite of many atmospheric variables to monitor regional climate changes and locate global teleconnection patterns.