The occurrence of African dust outbreaks over the whole Mediterranean Basin has been studied on an 11-yr period (2001–2011). In order to evaluate the impact of such mineral dust outbreaks on ambient concentrations of particulate matter, PM₁₀ data from regional and suburban background sites across the Mediterranean area were compiled. After identifying the daily influence of African dust, a methodology for the estimation of the natural dust contributions on daily PM₁₀ concentrations was applied. <br><br> Our findings point out that African dust outbreaks are sensibly more frequent in southern sites across the Mediterranean, from 30 to 37% of the annual days, whereas they occur less than 20% of the annual days in northern sites. The central Mediterranean emerges as a transitional area, with slightly higher frequency of dust episodes in its lower extreme when compared to similar latitudinal positions in western and eastern sides of the Basin. A decreasing south to north gradient of African dust contribution to PM₁₀, driven by the latitudinal position of the monitoring sites at least 25° E westwards across the Basin, is patent across the Mediterranean. As a result of this, an experimental equation for the estimation of annual African dust contributions based on the latitudinal position was obtained. From 25° E eastwards, higher annual dust contributions are encountered due to the elevated annual occurrence of severe episodes of dust but also because of inputs from Negev and Middle Eastern deserts. The slightly higher frequency of African dust episodes observed over southern sites in the central Mediterranean Basin is compensated by its moderately lower intensity. Concerning seasonality patterns and intensity characteristics, a clear summer prevalence is observed in the western part, with low occurrence of severe episodes (daily dust averages over 100 μg m⁻³ in PM₁₀); no seasonal trend is detected in the central region, with moderate-intensity episodes; and significantly higher contributions are common in autumn-spring in the eastern side, with occurrence of various severe episodes throughout the year. Overall, African dust emerges as the largest PM₁₀ source in regional background southern sites of the Mediterranean (35–50% of PM₁₀), with seasonal peak contributions to PM₁₀ up to 80% of the total mass. <br><br> The multi-year study of African dust episodes and their contributions to PM₁₀ concentrations reveals a consistent decreasing trend in the period 2006/2007 to 2011 in 4 of the 17 studied regions, all of them located in the NW of the Mediterranean. Such decrease is almost parallel to that of the NAO (North Atlantic Oscillation) index for the summer period, progressively more negative since 2006. Therefore, a sharp change in the atmospheric circulation over the last 5 yr (a similar negative NAO period occurred in the 1950 decade) have affected the number of African dust episodes and consequently the annual dust inputs to PM₁₀ observed in the NW part of the Mediterranean. By investigating mean temperatures and geopotential height maps at 850 hPa it is evident a displacement of warm air masses accomplishing African dust towards the central Mediterranean in the 2007–2008 biennium, and towards the NW African coast and the Canary Islands in the 2009–2011 triennium.