The contribution of atmospherically persistent (long-lived) greenhouse gases to the radiative forcing of Earth has increased over the past several decades. The impact of highly fluorinated, saturated compounds, in particular perfluorinated compounds, on climate change is a concern because of their long atmospheric lifetimes, which are primarily determined by stratospheric loss processes, as well as their strong absorption in the infrared "window" region. A potentially key stratospheric loss process for these compounds is their gas-phase reaction with electronically excited oxygen atoms, O(<sup>1</sup>D). Therefore, accurate reaction rate coefficient data is desired for input to climate change models. In this work, rate coefficients, <i>k</i>, were measured for the reaction of O(<sup>1</sup>D) with several key long-lived greenhouse gases, namely NF<sub>3</sub>, SF<sub>5</sub>CF<sub>3</sub>, CHF<sub>3</sub> (HFC-23), C<sub>2</sub>F<sub>6</sub>, c-C<sub>4</sub>F<sub>8</sub>, <i>n</i>-C<sub>5</sub>F<sub>12</sub>, and <i>n</i>-C<sub>6</sub>F<sub>14</sub>. Room temperature rate coefficients for the total reaction, <i>k</i><sub>Tot</sub>, corresponding to loss of O(<sup>1</sup>D), and reactive channel, <i>k</i><sub>R</sub>, corresponding to the loss of the reactant compound, were measured for NF<sub>3</sub> and SF<sub>5</sub>CF<sub>3</sub> using competitive reaction and relative rate methods, respectively. <i>k</i><sub>R</sub> was measured for the CHF<sub>3</sub> reaction and improved upper-limits were determined for the perfluorinated compounds included in this study. For NF<sub>3</sub>, <i>k</i><sub>Tot</sub> was determined to be (2.55 ± 0.38) × 10<sup>−11</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup> and <i>k</i><sub>R</sub>, which was measured using CF<sub>3</sub>Cl, N<sub>2</sub>O, CF<sub>2</sub>ClCF<sub>2</sub>Cl (CFC-114), and CF<sub>3</sub>CFCl<sub>2</sub> (CFC-114a) as reference compounds, was determined to be (2.21 ± 0.33) × 10<sup>−11</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup>. For SF<sub>5</sub>CF<sub>3</sub>, <i>k</i><sub>Tot</sub> = (3.24 ± 0.50) × 10<sup>−13</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup> and <i>k</i><sub>R</sub> < 5.8 × 10<sup>×14</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup> were measured, where <i>k</i><sub>R</sub> is a factor of three lower than the current recommendation of <i>k</i><sub>Tot</sub> for use in atmospheric modeling. For CHF<sub>3</sub> <i>k</i><sub>R</sub> was determined to be (2.35 ± 0.35) × 10<sup>−12</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup>, which corresponds to a reactive channel yield of 0.26 ± 0.04, and resolves a large discrepancy among previously reported values. The quoted uncertainties are 2σ and include estimated systematic errors. Upper-limits for <i>k</i><sub>R</sub> for the C<sub>2</sub>F<sub>6</sub>, c-C<sub>4</sub>F<sub>8</sub>, <i>n</i>-C<sub>5</sub>F<sub>12</sub>, and <i>n</i>-C<sub>6</sub>F<sub>14</sub> reactions were determined to be 3.0, 3.5, 5.0, and 16 (in units of 10<sup>−14</sup> cm<sup>3</sup> molecule<sup>−1</sup> s<sup>−1</sup>), respectively. The results from this work are compared with results from previous studies. As part of this work, infrared absorption band strengths for NF<sub>3</sub> and SF<sub>5</sub>CF<sub>3</sub> were measured and found to be in good agreement with recently reported values.